subcutaneous glucose sensing dexcom seven plus sensors  (Dexcom Inc)

Journal: Journal of process control

Article Title: A New Animal Model of Insulin-Glucose Dynamics in the Intraperitoneal Space Enhances Closed-Loop Control Performance

doi: 10.1016/j.jprocont.2019.01.002

Figure Lengend Snippet: Closed-loop robustness analysis of the proposed IP-IP controller (green) vs. the proposed IP-SC controller with subcutaneous sensing (red), and the IP-IP PID controller (black) designed by Huyett et al 24. [A] Median glucose trajectories in mg/dL with unannounced meals (inverted cyan triangles) and effect of exercise input (red triangle). Set point is at 110 mg/dL. [B] Corresponding median insulin delivery in U/5 min. [C] Comparison of the percent time in hypoglycemia (< 70 mg/dL). [D] Comparison of the percent time in glycemic safe zone (within 70–180 mg/dL). [E] Comparison of the percent time in hyperglycemia (>180 mg/dL).

Article Snippet: Ten adults (7 male, 3 female) with T1DM participated in a non-randomized, non-blinded sequential AP study ‡ using subcutaneous glucose sensing via Dexcom Seven Plus sensors (Dexcom, San Diego, USA) and zone MPC modified[ 31 ] for IP delivery via the Diaport system (Second Generation, Roche Diagnostics, Mannheim, Germany).

Techniques: Comparison

Journal: Journal of Diabetes Science and Technology

Article Title: Safe Glycemic Management during Closed-Loop Treatment of Type 1 Diabetes: The Role of Glucagon, Use of Multiple Sensors, and Compensation for Stress Hyperglycemia

doi:

Figure Lengend Snippet: A frequency histogram of sensor accuracy (ARD) obtained in subcutaneous amperometric sensors (Dexcom® SEVEN® PLUS) in persons with T1DM during closed-loop glycemic control studies. Sensors were calibrated every 6 h with arterialized venous blood using a very accurate glucose measurement device (Hemocue 201). Although mean ARD indicates very good accuracy, it should be noted that a small percentage of readings indicate poor sensor accuracy that may lead to insulin delivery errors during closed-loop treatment. CGM, continuous glucose monitoring; BG, blood glucose.

Article Snippet: Each subject had two subcutaneous Dexcom SEVEN PLUS sensors.

Techniques: Control

Journal: Journal of Diabetes Science and Technology

Article Title: Safe Glycemic Management during Closed-Loop Treatment of Type 1 Diabetes: The Role of Glucagon, Use of Multiple Sensors, and Compensation for Stress Hyperglycemia

doi:

Figure Lengend Snippet: (A) A frequency histogram obtained in subcutaneous amperometric sensors (Dexcom® SEVEN® PLUS) in 14 persons with T1DM, each during 66 hours of closed-loop monitoring and treatment. Each subject had two subcutaneous Dexcom SEVEN PLUS sensors. At each time point, simple sensor error was measured (sensor glucose – venous reference Hemocue glucose) in a random sensor (blue) and the average of the two sensors (red). Note Gaussian distribution of both data sets with very low skewness coefficients, indicating symmetry. There was a slight negative bias of –8.5–10 mg/dl for both data sets. (B) The same frequency histogram as in Figure 4A, now plotted on an expanded y-axis in order to discriminate better between the distribution of random versus average data values. Especially at the tails, the average values have a substantially lower error than the random sensor values. For averaged values, there were only 1.2% of values that were either less than -60 mg/dl or greater than 60 mg/dl (as compared to 2.7% of the randomly chosen values).

Article Snippet: Each subject had two subcutaneous Dexcom SEVEN PLUS sensors.

Techniques:

Journal: Journal of Diabetes Science and Technology

Article Title: Safe Glycemic Management during Closed-Loop Treatment of Type 1 Diabetes: The Role of Glucagon, Use of Multiple Sensors, and Compensation for Stress Hyperglycemia

doi:

Figure Lengend Snippet: A frequency histogram of sensor accuracy (ARD) obtained in subcutaneous amperometric sensors (Dexcom® SEVEN® PLUS) in persons with T1DM during closed-loop glycemic control studies. Sensors were calibrated every 6 h with arterialized venous blood using a very accurate glucose measurement device (Hemocue 201). Although mean ARD indicates very good accuracy, it should be noted that a small percentage of readings indicate poor sensor accuracy that may lead to insulin delivery errors during closed-loop treatment. CGM, continuous glucose monitoring; BG, blood glucose.

Article Snippet: With the use of standard outpatient glucose meters as the calibrating instrument, there would undoubtedly be a greater number of large sensor errors. fig ft0 fig mode=article f1 fig/graphic|fig/alternatives/graphic mode="anchored" m1 Open in a separate window caption a7 A frequency histogram of sensor accuracy (ARD) obtained in subcutaneous amperometric sensors (Dexcom® SEVEN® PLUS) in persons with T1DM during closed-loop glycemic control studies.

Techniques: Control

Journal: Journal of Diabetes Science and Technology

Article Title: Safe Glycemic Management during Closed-Loop Treatment of Type 1 Diabetes: The Role of Glucagon, Use of Multiple Sensors, and Compensation for Stress Hyperglycemia

doi:

Figure Lengend Snippet: (A) A frequency histogram obtained in subcutaneous amperometric sensors (Dexcom® SEVEN® PLUS) in 14 persons with T1DM, each during 66 hours of closed-loop monitoring and treatment. Each subject had two subcutaneous Dexcom SEVEN PLUS sensors. At each time point, simple sensor error was measured (sensor glucose – venous reference Hemocue glucose) in a random sensor (blue) and the average of the two sensors (red). Note Gaussian distribution of both data sets with very low skewness coefficients, indicating symmetry. There was a slight negative bias of –8.5–10 mg/dl for both data sets. (B) The same frequency histogram as in Figure 4A, now plotted on an expanded y-axis in order to discriminate better between the distribution of random versus average data values. Especially at the tails, the average values have a substantially lower error than the random sensor values. For averaged values, there were only 1.2% of values that were either less than -60 mg/dl or greater than 60 mg/dl (as compared to 2.7% of the randomly chosen values).

Article Snippet: With the use of standard outpatient glucose meters as the calibrating instrument, there would undoubtedly be a greater number of large sensor errors. fig ft0 fig mode=article f1 fig/graphic|fig/alternatives/graphic mode="anchored" m1 Open in a separate window caption a7 A frequency histogram of sensor accuracy (ARD) obtained in subcutaneous amperometric sensors (Dexcom® SEVEN® PLUS) in persons with T1DM during closed-loop glycemic control studies.

Techniques: